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Pharmacodynamics

The MEU has extensive experience and validated models to assist in achieving primary, secondary and exploratory endpoints for our clients.

We have access to specialised assessments and equipment through our healthcare and academic partners within Manchester.

General

  • ECG
  • Telemetry
  • ECHO
  • Ambulatory Blood Pressure and ECG
  • Sleep Studies
  • EEG
  • NCS/EMG
  • Endoscopy
  • Lumbar Puncture
  • Skin Biopsy
  • Muscle Biopsy
  • Adrenal Testing
The MEU has extensive experience and validated models to assist in achieving primary, secondary and exploratory endpoints for our clients
The MEU has access to specialised assessments and equipment through our healthcare and academic partners within Manchester

Imaging

Full range of medical imaging including:

  • Nuclear Medicine
  • PET CT
  • HRCT
  • Functional MRI (Phillips 3.2 Release MRI) PD model
  • Ultrasound
  • X-Ray
  • Interventional Radiology

Respiratory Capabilities

  • Whole body plethysmography/DLCo
  • Impulse Oscillometry/spirometry
  • Exhaled nitric oxide/breath condensate
  • Induced sputum
  • Nasal challenge
  • Transfer Factor
  • Bespoke Bronchoscopy Suite: Bronchoscopy with lavage and bio Inhalational
  • Bronchial challenges of allergens or other mediators (methacholine, histamine, AMP, leukotriene D4, lipoplysaccharide LPS)
The MEU’s respiratory capabilities
The MEU lung function laboratory

Challenge Models

  • Cough Challenge : Capsaicin; ATP; Citric Acid
  • Bronchial Challenge : Cat; Dog; HDM; Grass Pollen
  • Nasal Challenge
  • Food Challenge : Peanut
  • Intradermal Challenge
  • Pain : UVB challenge

Rhinovirus Challenge Models

  • Experienced in rhinovirus studies
  • On-site liquid nitrogen storage for rhinovirus
  • Individual isolation booths on-site, ideal for rhinovirus administration
  • Dedicated SOP for the administration of HRV and management of subjects
  • Experienced science team proficient with handling post-RV samples
  • GLP validated standards for Viral antibody titres and PCR

Central Nervous System

  • Capacity assessment and informed consent
  • Improved selection of patient population through experience
  • Use of recognised screening tools (Structured Clinical Interview for DSM (SCID), MINI (Mini-International Neuropsychiatric Interview) and rating scales (Beck Depression Inventory (BDI), Montgomery Asberg Depression Rating Scale (MADRS), Columbia-Suicide Severity Rating Scale (C-SSRS), Clinician Administered Dissociative States Scale (CADSS), Visual Analogue Scales (VAS)
  • Static and Functional Imaging: fMRI ( Blood Oxygen Level Dependent (BOLD), Arterial Spin Labelling (ASL), Magnetic Resonance Spectroscopy(MRS). Pharmacological MRI (phMRI), resting stating fMRI) including neuropsychological test batteries and its analysis
  • Clinical Psychologist/Raters for neuropsychological test batteries
  • Experienced in Lumbar Puncture and CSF collection
A patient consultation