- Cough Challenge : Capsaicin; ATP; Citric Acid
- Bronchial Challenge : Cat; Dog; HDM; Grass Pollen
- Nasal Challenge
- Food Challenge : Peanut
- Intradermal Challenge
- Pain : UVB challenge
Pharmacodynamics
The MEU has extensive experience and validated models to assist in achieving primary, secondary and exploratory endpoints for our clients.
We have access to specialised assessments and equipment through our healthcare and academic partners within Manchester.
General
- ECG
- Telemetry
- ECHO
- Ambulatory Blood Pressure and ECG
- Sleep Studies
- EEG
- NCS/EMG
- Endoscopy
- Lumbar Puncture
- Skin Biopsy
- Muscle Biopsy
- Adrenal Testing
Imaging
Full range of medical imaging including:
- HRCT
- Functional MRI (Phillips 3.2 Release MRI) PD model
- Ultrasound
- X-Ray
- Interventional Radiology
Respiratory Capabilities
- Whole body plethysmography/DLCo
- Impulse Oscillometry/spirometry
- Exhaled nitric oxide/breath condensate
- Induced sputum
- Nasal challenge
- Transfer Factor
- Bespoke Bronchoscopy Suite: Bronchoscopy with lavage and bio Inhalational
- Bronchial challenges of allergens or other mediators (methacholine, histamine, AMP, leukotriene D4, lipoplysaccharide LPS)
Challenge Models
Rhinovirus Challenge Models
- Experienced in rhinovirus studies
- On-site liquid nitrogen storage for rhinovirus
- Individual isolation booths on-site, ideal for rhinovirus administration
- Dedicated SOP for the administration of HRV and management of subjects
- Experienced science team proficient with handling post-RV samples
- GLP validated standards for Viral antibody titres and PCR