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 Medicines Evaluation Unit - Previous Studies - Abstracts

Abstracts/Posters

1. Langley S J, Murdoch R D, Compton C H, Masterson C M, Woodcock A A. Lack of bronchodilatory effect of BRL 55834 (a selective potassium channel activator) in asthmatic patients. Am J Respir Crit Care Med 1996; 153 (4):A804.

2. Langley S J, Masterson C M, Batty E P, Woodcock A. Bronchodilator response to salbutamol after chronic dosing with salmeterol. Am J Respir Crit Care Med 1997; 155 (4):A345.

3. Langley S J, Svanberg C. A study assessing the efficacy of one sodium cromoglycate capsule from Spinhaler vs Eclips in AMP challenge. Allergy 1997; 37:188.

4. Langley S J, Woodcock. Salbutamol dose response after chronic treatment with salmeterol. Eur Respir J 1997; 10 (suppl 25):2s.

5. Jones M, Langley S J. The role of saline as a baseline in histamine challenges. Eur Respir J 1997; 10 (suppl 25):57s.

6. Simpson A, Custovic A, Adisesh A, Pipis S, Hallam C, Craven M, Cain G, Langley S J, Faragher E B, Woodcock A. Exhaled nitric oxide (eNO) in relation to sensitisation and exposure to indoor allergens in asthmatics. American Academy of Allergy and Immunology meeting, Washington February 1998.

7. Langley S J, Masterson C M, Batty E P, Jones M. The subjective sensation of chest tightness during bronchodilation in asthmatics. Am J Respir Crit Care Med 1998; 157/3):A920.

8. Langley S J, Masterson C M., Batty E P, Jones M, Sykes A, Bogolubov M, Stahl E G, Woodcock A. Comparison of single doses of HFA 134A propellant and CFC salbutamol in mild to moderate asthmatic patients. Eur Respir J 1998; 12 (suppl 28):67s.

9. Villeran C, O'Neill S O, Helbling A, Van Noord J A, Lee T, Chuchalin A G, Langley S J, Gunewardena K, Suskovic S, Laurenzi M, Jasan J, Leff J A. Montelukast compared to Salmeterol in the treatment of exercise-induced asthma (EIA). Eur Respir J 1998; 12 (suppl 28):361s.

10. Compton C, Cedar E, Nieman RB, Amit O, Langley S J, Sapene M. Ariflo improves pulmonary function in patients with asthma: results of a study in patients taking inhaled corticosteroids. Am J Respir Crit Car Med 1999; 159/3:A624.

11. Jones M, Langley S J, Masterton C M, Batty E P. Correlation of airways resistance measured using the interrupter technique (MicroRint) with standard spirometry. Am J Respir Crit Car Med 1999; 159/3:A651.

12. Langley S J, Jones M, Williams A J, Batty E P. Assessment of a hand held interrupter device (MicroRint) to measure bronchodilator effects in adult asthmatics. Am J Respir Crit Car Med 1999; 159/3:A652

13. Langley S J, Masterson CM, Batty E P, Jones M. Assessment of a hand held interrupter device (MicroRint) to measure bronchodilator effects in healthy volunteers. Eur Respir J 1999; 13 (suppl ):71s.

14. Brutsche M H, Brutsche I C, Munavvar M, Langley S J, Masterson C, Daley-Yates P T, Brown R, Woodcock A. Pharmacokinetics and systemic effects of inhaled fluticasone propionate (FP) are different in asthmatics (A) and normal volunteers. Eur Respir J 1999; 12 (suppl): 345s.

15. Compton C, Cedar E, Nieman RB, Amit O, Langley S J, Sapene M. SB 207499 improves pulmonary function in patients with asthma receiving inhaled corticosteroids. Eur Respir J 1999; 12 (suppl): 288s.

16. Langley S, Woodcock A, Jones S.W., Rice L. A placebo controlled comparison of single doses of salmeterol and the combination bronchodilator Combivent on lung function over 12 hours in patients with chronic obstructive pulmonary disease (COPD). BMJ 1999; 54 (suppl 3), A65

17. JC. Kips, BJ. O'Connor, SJ. Langley, A. Woodcock, HAM. Kerstjenens, DS Postma, M. Danzig, F. Cuss, RA. Pauwels. Results of a Phase I trial with SCH55700, A humanized anti-IL5 antibody, in severe persistent asthma. Am J Respir Crit Car Med 2000; 16, 161:A505

18. P.T. Daley-Yates, J. Tournant, M.H. Brutsche, I. Carlen-Brutsche, M. Munavar, S. Langley, C. Masterson, A.A. Woodcock. Pulmonary absorption kinetics of fluticasone propionate (FP) in healthy subjects and asthmatics. Am J Respir Crit Car Med 2000,; 16, 161:A774

19. A. Frew, S.J.Langley, E.Gooden. Therapeutic equivalence of inhaled budesonide (100mg bd) delivered by either a new multi-dose dry powder inhaler (Airmax™) or a conventional dry powder inhaler (Turbohaler®) using airways reactivity to inhaled adenosine 5’-monophosphate in asthmatic subjects. ERS, Florence, Aug 2000.

20. P.T. Daley-Yates, J. Tournant, M.H. Brutsche, I. Carlen-Brutsche, M. Munavar, S. Langley, C. Masterson, A.A. Woodcock. Lung residence time and absorption rate for inhaled fluticasone propionate (FP) in healthy subjects and asthmatics. Eur Respir J 2000;16 (suppl 31): 279s.

21. SJ Langley, S Goldthorpe, A Woodcock, A Custovic. Effect of atopy and exposure to indoor allergens on lung function and airway reactivity in asthma. Am J Respir Crit Car Med 2001;163:5:A602

22. S Goldthorpe, SJ Langley, M Craven, A Simpson, A Custovic, A Woodcock. Sensitisation and exposure to indoor allergens increases exhaled nitric oxide in asthma. Am J Respir Crit Car Med 2001;163:5:A720

23. SJ Langley, S Goldthorpe, C Hallam, A Custovic, A Woodcock. Exhaled nitric oxide, bronchial reactivity and pulmonary function in asthma. Am J Respir Crit Car Med 2001;163:5:A421

24. SJ Langley, A Derham, J Holden, C Whale, D Mukherjee, P Hedgland, A Woodcock. Comparison of efficacy of fluticasone HFC 134a metered dose inhaler and fluticasone (dry powder) diskhaler. Am J Respir Crit Car Med 2001;161:5:A441.

25. SD Singh, C Whale, A Hatton, N Houghton, N Raza, PT Daly-Yates, AA Woodcock. Comparison of the pharmacokinetics of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease and healthy subjects. American Journal Of Respiratory & Critical Care Medicine, April 2001:

26. K Wilson, SD Singh, AA Woodcock. An audit of the use of salbutamol in mild asthmatics. American Journal Of Respiratory & Critical Care Medicine, April 2001:

27. C Whale, SD Singh, AA Woodcock. The reproducibility of capsaicin cough in healthy subjects. American Journal Of Respiratory & Critical Care Medicine, April 2001:

28. SD Singh, A Hatton, C Sutton And AA Woodcock. Repeat tuberculin testing at 1 week causes a booster effect in UK subjects. American Journal Of Respiratory & Critical Care Medicine, April 2001.

29. C Whale, SD Singh, N Houghton, A Hatton, AA Woodcock. Salbutamol induced changes in ventilation-perfusion and pulse in chronic obstructive pulmonary disease. American Journal Of Respiratory & Critical Care Medicine, April 2001:

30. J. F. Donohue, J. A. van Noord, S. J. Langley, A. Lee, S. Kesten, L. J. Towse. Superior bronchodilation of once daily tiotropium compared to twice daily salmeterol in patients with COPD. Eur Respir J 2001;18(suppl 33):26s

31. S. J. Langley, S. Goldthorpe, A. Custovic, A. A. Woodcock. Effect of disease duration on pulmonary function in asthma. Eur Respir J 2001;18(suppl 33):34s.

32. S. J. Langley, B. McDonnell, D. Allen, N. Wheeler, M. Briggs, A. A. Woodcock. Effect of fine particle mass (FPM) on the bronchodilator and bronchoprotective properties of salmeterol. Eur Respir J 2001;18(suppl 33):101s

33. S. J. Langley, S. Goldthorpe, A. Custovic, A. Woodcock. Allergen exposure in non-dog and non-house dust mite sensitized atopic asthmatic subjects; effect on bronchial reactivity. Eur Respir J 2001;18(suppl 33):482s.

34. D.J. Allen, K. Wilson, R. Bright-Thomas, B. McDonnell and S.D. Singh. The Pharmacology of Leukotriene D4 Induced Inflammation in Human Skin. British Pharmacology Journal, 2001.

35. S Langley, L Towse, S Kesten, PM Calverley. Heart rate and rhythm analysis from holter monitoring in COPD patients receiving tiotropium. Am J Respir Crit Car Med 2002;165:8:A592

36. C.E. Austin, S.T. Woolley, M. Christie, S. Langley, C. Taylor, A. Young and C.A. Sargent.CXCR1 and CXCR2 expression on leukocytes from normal and COPD patients. Am J Respir Crit Car Med 2002;165:8:A597.

37. Terry Woolley, Carol Weyman-Jones, Stephen Langley, Alan Young and Carol Sargent Systemic levels of IL-1Ra and IL-s1r11 are modulated in stable COPD patients. Am J Respir Crit Car Med 2002;165:8:A597

38. D Acerbi , P Daley Yates , G Poli , A Woodcock , S Langley. Pharmacokinetics of a New CFC-free Metered Dose Inhaler of Beclomethasone Dipropionate Following Multiple Dosing in AsthmaticPatients. Respiratory Drug Delivery VIII, 2002, Vol 2, pp 395-398

39. A.A.Woodcock, I.D.Pavord, L.Rice and T.P.McCarthy. A comparison of the anti-inflammatory and clinical effects of salmeterol/fluticasone propionate combination (SFC) with fluticasone propionate (FP) plus montelukast (M) in patients with mild to moderate asthma. ATS 2003

40. D.J. Allen, R.J. Bright-Thomas, B.M. McDonnell, A. Pankhania, E.P. Batty, S.J. Langley, A. Rossetti and A. Woodcock. A single centre open study into the safety of Pulvinal™, a new dry powder beclomethasone dipropionate (BDP) inhaler in the treatment of mild to severe asthmatics. ATS 2003

41. Stephen J Langley, Elizabeth P Batty, Catherine M Masterson, Luca Cantini, and Ashley Woodcock. Comparison of single doses of salbutamol delivered from a metered dose inhaler (MDI) and a novel dry powder inhaler (DPI) in asthmatic patients. ATS 2003

42. C.M.Houghton, S.D.Singh and A.A Woodcock. Reproducibility of Impulse Oscillometry, Plethysmography and Spirometry in Asthmatic and Healthy Subjects. AmJRCCM ;2003: 167;7 A141.

43. C Houghton, SJ Langley, J Holden, SD Singh, A Rossetti, L Cantini, A Woodcock. Comparison of Formoterol HFA-134a Modulite™, Foradil™ CFC and Foradil™ Aerolizer™ and placebo on the bronchoprotective and bronchodilator effects in a double blind, double dummy, cross-over study. asthma, volume 4, supplement 1, 2003, a38

44. DJ Allen, S Percy, SJ Langley, A Woodcock. Regular inhaled combination therapy provides sustained improvement in lung function in asthmatic adults. World Asthma Meeting, Bangkok, 2004
  

31 Jan 2017

Visit us at DIA Euromeeting

29th - 31st March at SECC, Glasgow

 

and BIO International Convention

19th - 22nd June in San Diego

 

11 Nov 2015

Sir Alex Ferguson opens new Bronchoscopy unit at MEU

 

2 Oct 2015

MEU-Partnership project (KTP008776) nominated for KTP Awards 2015

 

1 Oct 2015

Watch Professor Singh speaking about COPD Patients and the importance of reducing the risk of exacerbations at ERS 2015 in Amsterdam.

 

1 Oct 2015

Verona Pharma’s respiratory drug proves positive in study

 

25 Sept 2015

The new bronchoscopy unit at UHSM, funded by the MEU is now in operation allowing the MEU to increase its bronchoscopy capacity. The unit will be officially opened by Sir Alex Ferguson on Mon 9th November 2015

 

 

22 October 2014

The MEU and Knowledge Transfer Partnership work has been chosen as an example of excellence in the

"North West Innovation case book" - see page 19

 

24 June 2014

2014 World Asthma day

Listen to John Goddard, Volunteer Services Advisor, interview on Wythenshawe FM for World Asthma day

 

11 February 2014

MEU Clinical Physiology Manager receives John Coates award at ARTP conference gala dinner.

More....

 

11 May 2012

“The MEU are pleased to announce the completion of our new extension, expanding the total bed capacity from 18 to 36, increasing our out-patient facilities, doubling the size of the volunteer lounge and extending first floor offices.”

 

5 August 2011

The MEU is pleased to announce that we are now accredited with the ISO9001:2008 Quality Management Systems award.

 

7 November 2010

Wythenshawe Hospital COPD Day

Listen to Maggie Adu, Volunteer Services Advisor, talking about the COPD Day.

 

 

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